In Vitro Experiment

Title Average Ratingsort ascending
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells 100.00%
Potent antiviral effect of silver nanoparticles on SARS-CoV-2 100.00%
Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancer. 90.00%
Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prosta 90.00%
Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation. 90.00%
Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of the AMPA receptor. 90.00%
Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure 90.00%
20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and 90.00%
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis. 90.00%
In-vitro toxicity of Ukrain against human Ewing tumor cell lines. 90.00%
Effect of Ukrain on the growth and metastasizing of Lewis carcinoma in C57BL/6 mice 90.00%
Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a 90.00%
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. 85.00%
Effect of Ukrain on matrix metalloproteinase-2 and Secreted Protein Acidic and Rich in Cysteine (SPARC) expression in human.... 80.00%
Ukrain acts by inhibition of tubulin polymerization in normal and malignant cell lines. 80.00%
Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect. 80.00%
In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds 80.00%
SARS-CoV-2 Viral Culturing at CDC 80.00%
Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour ce 80.00%
Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy 80.00%
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort 80.00%
The influence of glucose, succinate, pH of the medium and higher temperature on the cytotoxic activity of the preparation Ukrain 80.00%
Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. 80.00%
Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy. 80.00%
Sanguinarine suppresses prostate tumor growth and inhibits survivin expression. 80.00%
ROS production and angiogenic regulation by macrophages in response to heat therapy. 80.00%
N-acetylcysteine inhibits proliferation, adhesion, migration and invasion of human bladder cancer cells. 80.00%
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission 80.00%
Evaluation of anticancer activities of benzo phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line. 80.00%
Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase 80.00%
National Cancer Institute, National Institute of Health: Developmental Therapeutics Program. NSC 631570: results of the Human Ce 80.00%
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. 80.00%
Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins 80.00%
Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. 80.00%
The antimitotic effects of Ukrain, a Chelidonium majus alkaloid derivative, are reversible in vitro. 80.00%
Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in 80.00%
Induced G2/M arrest and apoptosis in human epidermoid carcinoma cell lines by semisynthetic drug Ukrain 80.00%
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expressio 80.00%
Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells. 80.00%
Effect of emodin combined gemcitabine on the growth and apoptosis of pancreatic cancer cell line BxPC-3 in vitro 80.00%
Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their de 80.00%
Induction of apoptosis in cultured Chinese hamster ovary cells by Ukrain and its synergistic action with etoposide. 80.00%
In vitro induction of apoptotic cell death in chronic lymphocytic leukemia by two natural products: preliminary study 70.00%
Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemi 70.00%
The inhibition of glioma growth in vitro and in vivo by a chitosan/ellagic acid composite biomaterial. 70.00%
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in th 70.00%
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes 70.00%
Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells. 70.00%
Anticancer Effect of Dihydroartemisinin (DHA) in a Pancreatic Tumor Model Evaluated by Conventional Methods and Optical Imaging. 70.00%
The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways 70.00%
Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain 70.00%
Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. 70.00%
NF-kappaB does not influence the induction of apoptosis by Ukrain. 70.00%
Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase path-- 60.00%
Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of 60.00%
Fibronectin and laminin increase resistance to ionizing radiation and the cytotoxic drug Ukrain in human tumour and normal cells 60.00%
The influence of the novel drug Ukrain on hemo- and immunopoiesis at the time of its maximum radioprotective effect 60.00%
1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2), potentiate the effects of ionising.. 60.00%
Bcl-2 overexpression protects human keratinocyte cells from Ukrain-induced apoptosis but not from G2/M arrest. 60.00%
Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. 60.00%
Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and m 60.00%
Radiomodification effects of Ukrain, a cytostatic and immunomodulating drug, on intracellular glucocorticoid reception during sh 60.00%
Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo 60.00%
Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate 60.00%
Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glyc 60.00%
Enhanced proliferation and potassium conductance of Schwann cells isolated from NF2 schwannomas can be reduced by quinidine. 60.00%
Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. 60.00%
Cysteine proteinases and their inhibitors in the development of mouse HA-1 hepatoma and antineoplastic therapy 60.00%
A study of the influence of a novel drug Ukrain on in vivo effects of low-dose ionizing radiation 50.00%
Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata. 50.00%
A method for determination of Ukrain in blood plasma for monitoring and pharmacokinetic study 50.00%
Comparative in vitro study of the effects of the new antitumor drug Ukrain and several cytostatic agents on the thiol groups in 50.00%
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosp 50.00%
c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of non 50.00%
Ukrain modulates glial fibrillary acidic protein, but not connexin 43 expression, and induces apoptosis in human cultured gliobl 50.00%
Ukrain (NSC-631570) influences on bone status: a review. 50.00%
Biological activity of some thiophosphamide derivatives of alkaloids with respect to influenza virus 50.00%
Inhibition of angiogenesis by non-toxic doses of temozolomide. 50.00%
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. 50.00%
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. 50.00%
Influence of Ukrain on the nuclear thyroid hormone receptors after short-term gamma-irradiation. 50.00%
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. 50.00%
Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma. 50.00%
Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase 50.00%
Effect of alkaloid sanguinarine and a pharmaceutical preparation ukrain on modulation of vesicular membrane fusion and actin.... 50.00%
Enhancement of macrophage tumouricidal activity by the alkaloid derivative 40.00%
Inhibition of MIF Leads to Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells. 40.00%
Ukrain: acute toxicity after intravenous, intramuscular and oral administration in rats 40.00%
Hepatocyte growth factor as inducer of gefitinib resistance in non-small cell lung cancer harboring EGFR activating mutations. 40.00%
In vitro and in vivo antiproliferative activity of laherradurin and cherimolin-2 of Annona diversifolia Saff. 40.00%
Kinetics study on markers of the immune system by gene expression profiling of an in vivo heated tumor. 40.00%
Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome 30.00%
Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of m 30.00%
Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice. 30.00%
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. 20.00%
Effect of Ukrain on human liver alcohol dehydrogenase activity in vitro.
Induced apoptosis in human prostate cancer cell line LNCaP by Ukrain.
Evaluation of mutagenic, genotoxic and transforming properties of Ukrain