Background: Glucose-6-phosphate dehydrogenase deficiency (G6PD) is linked to hemolytic anemia with certain medications and is the most common enzyme deficiency worldwide. Although the American College of Rheumatology does not recommend routine testing for G6PD prior to initiation of hydroxychloroquine (HCQ), the package insert for HCQ does recommend careful use in patients with G6PD deficiency.

Methods: We identified eligible subjects seen at our tertiary care, urban medical center between 1997 and 2018. Case records were analyzed for G6PD deficiency, HCQ use, length of exposure to HCQ, demographic characteristics, and laboratory evidence of hemolysis.

Results: We found 5264 patients who were prescribed HCQ, of which 49.5% (2605 patients) were screened for G6PD deficiency. Of the screened patients, 36 were found to be G6PD-deficient. Of the G6PD-deficient patients, 18 were exposed to HCQ. No evidence of hemolysis was found in these exposed patients.

Conclusions: Despite more than 500 months of cumulative exposure time to HCQ, there were no cases of hemolysis. These findings are in line with recently published data and suggest that this interaction is not associated with clinically significant hemolysis in our population of mainly African American and Hispanic patients. Limitations to our study are potential bias due to case review design and lack of prior assessment of episodes of hemolysis before HCQ exposure. A high proportion of our patients were Hispanic, suggesting no increase of adverse events in this subgroup. A larger longitudinal trial would be needed to definitively answer the question of the safety of HCQ in G6PD-deficient patients

The coronavirus disease 2019 (COVID-19) is until today a global health emergency. In an immense efort, efective drugs against COVID-19 are searched and intensive researches on possible repurposing of antiviral agents are performed. Since chloroquine (CQ) and hydroxychloroquine (HCQ) have shown in vitro anti- COVID-19 activities, the potential efect of CQ/ HCQ to treat and/or prevent COVID-19 infection has caused global attention.

New variants are of no concern. There is no need to cancel summer holidays. Millions vaccinated, coupled with immunity from millions of prior infections means we can surf on the crest of the third wave, rather than being remotely concerned about it. In fact, the UK should open now. And vaccine passports, certificates, or whatever name they are being given, will do nothing to improve the health of the population – all headlines we have read and heard over the past week or so.

Fear of symptom-free transmission was a major driver of the highly restrictive mitigation measures imposed over the past year.

ard data on the true prevalence of asymptomatic COVID-19 spread remains elusive, with scientists struggling to quantify just how often carriers of the SARS-Cov-2 virus transmit it without outward signs of illness. 

We have just received confirmation that the case files in the P.U.B. prosecution of the four horsemen of the Covid Apocalypse, are with the court’s listing department, who expect a hearing will soon be listed, following checks by the legal team at Bromley Magistrates, to which it was transferred for processing and listing by the Westminster court.

Being moved to the court which deals with all PCPs (Private Criminal Prosecutions), it is anticipated the fireworks will start going off very soon.

From the very start of this extraordinary case, it was always known to have taken a goodly time in getting to its present position. The major fraud case against both the mortgage and banksters took nearly 10 years to get this far, so looking at 10 months down the line we know, not only the case is rock solid but als that there are a huge swathe of the legal system behind us and making swift passage for the case of the centuries. This will be the single biggest legal case in the history of the British Isles.

There are many side cases going on yet this one in the High Court, probably the Old Bailey, the Common Law court of the Land due to a jury of 12 good men and women true, will be the show stopper of all showstoppers. The brilliant point is that its huge impact will force by every rule book the BBC, ITV, SKY and others to report truth for the first time in decades. It will destroy the curtain they have used to cover up so much criminality.

"Retired Colonel Matt Hepburn, an army infectious disease physician heading up DARPA’s response to the pandemic, appeared on 60 Minutes to demonstrate the technology.

Holding up a vial of green tissue-like gel, which contains the chip, Hepburn proclaimed:

You put it underneath your skin and what that tells you is that there are chemical reactions going on inside the body, and that signal means you are going to have symptoms tomorrow.”

"On April 8, 2021, the Weimar Family Court ruled in summary proceedings (Ref.: 9 F 148/21) that two Weimar schools are prohibited, effective immediately, from requiring students to wear any type of mouth-nose covering (especially qualified masks such as FFP2 masks), to comply with AHA minimum distances, and/or to participate in SARS-CoV-2 rapid testing."

The United States gave a grant of $600,000 to the Wuhan Institute of Virology, and the decision wasn’t even scrutinized by the agency Dr. Anthony Fauci heads up. This per a new report from The Daily Caller which lays out in detail exactly how the transfer happened and the lack of oversight involved.

Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prion-like domains are critical for virulence and the development of therapeutic targets; however, the prion- like domains in the SARS-CoV-2 proteome have not been analyzed. In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein, since SARS-CoV-2 was the only coronavirus with a prion- like domain found in the receptor-binding domain of the S1 region of the spike protein. The presence and unique distribution of prion-like domains in the SARS-CoV-2 receptor-binding domains of the spike protein is particularly interesting, since although the SARS-CoV-2 and SARS-CoV S proteins share the same host cell receptor, angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 demonstrates a 10- to 20-fold higher affinity for ACE2. Finally, we identified prion-like domains in the α1 helix of the ACE2 receptor that interact with the viral receptor-binding domain of SARS-CoV-2. Taken together, the present findings indicate that the identified PrDs in the SARS-CoV-2 receptor-binding domain (RBD) and ACE2 region that interact with RBD have important functional roles in viral adhesion and entry.

Interpretation

Between Dec. 14, 2020, and Mar. 5, 2021, 31,079 reports of adverse events were submitted to VAERS, including 1,524 deaths, 5,507 serious injuries and 390 reports of Bell’s Palsy.

Look at the latest from CNBC - 1 in 3 Covid survivors suffers neurological or mental disorders, study finds

Lockdowns will likely become a thing of the past once England emerges from restrictions in June, Professor Chris Whitty has said, as he suggested Britain will treat coronavirus like the flu in the future.

England’s chief medical officer said the UK would have to learn to live with the virus, noting that up to 25,000 people can die in a bad flu year without the figure hitting the headlines.

• Dr. Kate Clancy, a University of Illinois associate professor, said that she'd heard people had experienced changes in their menstruation since getting vaccinated
• Her tweet prompted other women to share changes to their own periods
• Several reported that they were bleeding more heavily and for longer than they had before getting the vaccine 

Research on SARS-CoV-2 RNA by scientists at Harvard and MIT has implications for how mRNA vaccines could permanently alter genomic DNA, according to Doug Corrigan, Ph.D., a biochemist-molecular biologist who says more research is needed.