Is the SARS-CoV-2 Genome Valid?

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Is the SARS-CoV-2 Genome Valid?

A closer look at the first genetic reads mapping.




Aligning the original reads that are published by Wu et al. 2020 to the SARS-CoV-2 reference genome yields a coverage of 99.993%. However, a closer look at the alignments, specifically for the head & tail of the novel genome, reveals that none of the original reads match sufficiently enough to establish certainty about the validity of the reference genome.

At the minimum it should be shown, that:

  1. At least 10–20 reads that show a perfect alignment to the head & the tail.

  2. A complete genetic sequence (RNA) of ~30kb length exists in the sample.

To my knowledge, neither of these two conditions have been fulfilled, to this date.