Modification of antinociceptive action of morphine by Ukrain in rodents

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Drugs Exp Clin Res. 1992;18 Suppl:101-5. Modification of antinociceptive action of morphine by Ukrain in rodents. Jagie??o-Wójtowicz E, Kleinrok Z, Chodkowska A, Feldo M, Nowicky JW. Department of Pharmacology, Medical Academy, Lublin, Poland. Morphine-induced (0.1 mg/kg s.c.)antinociceptive action was determined in rodents by using the writhing syndrome, hot plate and tail-flick tests. Ukrain given i.p. in doses equivalent to 0.05 and 0.1 LD50 did not affect the reactivity of the mice in the writhing syndrome test. Only in a dose of 0.1 LD50 did Ukrain produce an antinociceptive effect in the hot-plate and tail-flick tests. Ukrain significantly enhanced the antinociceptive effect of morphine in the hot-plate and tail-flick tests. The action of morphine was significantly suppressed by Ukrain in the writhing syndrome test in mice. These results indicated that Ukrain modified the antinociceptive action of morphine. PMID: 1305035