Technologies to Address Global Catastrophic Biological Risks
Selfspreading vaccines are genetically engineered to move through populations like communicable diseases, but rather than causing
disease, they confer protection. The vision is that a small number of individuals in a target population could be vaccinated, and the
vaccine strain would then circulate in the population much like a pathogenic virus, resulting in rapid,´widespread immunity.
Self-Amplifying mRNA Vaccines:
SAM vaccines use the genome of a modified virus with positive sense RNA, which is recognizable to our human translational machinery. Once delivered inside a human cell, the SAM is translated and creates 2 proteins: an antigen of interest to stimulate an immune response, and a viral replicase for intracellular amplification of the vaccine. The ability of SAM to self-replicate
results in a stronger, broader, and more effective humoral and cellular immune response than some other vaccines.