Self-Amplifying/Self-Spreading mRNA vaccines

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Technologies to Address Global Catastrophic Biological Risks

Self-Spreading Vaccines:

Selfspreading vaccines are genetically engineered to move through populations like communicable diseases, but rather than causing
disease, they confer protection. The vision is that a small number of individuals in a target population could be vaccinated, and the
vaccine strain would then circulate in the population much like a pathogenic virus, resulting in rapid,´widespread immunity.

Self-Amplifying mRNA Vaccines:

SAM vaccines use the genome of a modified virus with positive sense RNA, which is recognizable to our human translational machinery. Once delivered inside a human cell, the SAM is translated and creates 2 proteins: an antigen of interest to stimulate an immune response, and a viral replicase for intracellular amplification of the vaccine. The ability of SAM to self-replicate
results in a stronger, broader, and more effective humoral and cellular immune response than some other vaccines.