Determination of the Effectiveness of Chlorine Dioxide in the Treatment of COVID 19

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Abstract

Introduction: The aim of this review is to determine the Effectiveness of Oral Chlorine Dioxide in the Treatmentof COVID 19.

Methods: Research on the mechanism of action of chlorine dioxide on viruses, on the oral consumption ofwater-solubilized Cl02 and on its toxicity was reviewed; a quasi-experimental investigation wasconducted on the use of oral water-soluble chlorine dioxide in the treatment of 20 patients withactive COVID19 infection, compared to a control group of 20 patients not treated with chlorinedioxide.

Results: To compare the effect in the experimental group versus the control group, a test of comparison of proportions and their confidence intervals was performed for the general symptoms, and for the VAS and Likert criteria, a paired test using the Wilcoxon-Mann-Whitney test (α: 95%) was performed . When comparing the experimental group with the control group on the seventh day after symptom manifestation, a significant difference was found in the experimental group with respect to the control group for the symptoms Fever (p: 0000), Cough (p: 0.0000), Chills (p: 0.0000) and Dyspnea (p: 0.0006). When performing the visual analogous comparison of pain in the control group and in the experimental group, it was found that in all the items that make up the scale decreased significantly in this group with respect to the control group (p: 0.0000; p:00017). On day 14 post-demonstration the difference was greater (p:0.000 ; p:0.0043). When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values of the parameters PC Reactive on day 7 (p: 0.0001) and DH Lactate (0.0036), with higher scores for the experimental group; Dimero-D on day 7 (p: 0.0194) and on day 14 (p:0.0029) ; difference was found in all parameters. The results overall (p <0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID19.

Conclusion: Chlorine dioxide is effective in the treatment of COVID19 and the mechanisms of action by which it acts to achieve it are proposed in this work. We recommend doing more research. We recommend conducting double-blind studies and delving into studies of toxicological safety and therapeutic efficacy of chlorine dioxide in pathologies of epidemiological impact in the near future.