The Hunt for a Vaccine
How the hunt for an HIV vaccine is helping research into Covid-19 – and vice-versa
'Several trials and ‘a rather innovative strategy’
'So what is the state of research today? “There is a very advanced trial in phase 3 that we expect results from in 2022,” Bruck-Landais said. This trial is testing a “mosaic” strategy, making it possible to use different pieces of the HIV virus, which correspond to different subtypes, with the aim of being able to prevent most of the virus that is in circulation worldwide.’
‘A trial for a preventative vaccine launched in France by the Vaccine Research Institute, a laboratory created by the French National Agency for Research on AIDS and Viral Hepatitis (ANRS) and the University of Paris-Est Créteil, is among other trials currently in phase 1.
This trial “is testing a rather innovative strategy to optimise dendritic cells: Central immune cells that orchestrate our immune response”, Bruck-Landais explained. The idea is to “target these cells so they can recognise HIV viruses and then present them with antigens in order to stimulate antibody production”.’
‘However the research director noted a positive corollary to the health crisis: It encouraged HIV and Covid-19 researchers to collaborate. This collaboration in particular opened up new avenues of study on messenger RNA technology, which is used for the Pfizer-BioNTech and Moderna Covid-19 vaccines. “This technology has never been tested for HIV, but researchers have been studying it for several months to apply it to HIV," said Bruck-Landais.
The two viruses are nonetheless very different, she said, noting that vaccine strategies tested for HIV have not been successful, whereas several Covid-19 vaccines have been found in record time. '
“One is the coronavirus – Sars-CoV-2 – and the other is a retrovirus – HIV," she explained. “HIV mutates enormously. In each viral cycle, every time it multiplies, it generates at least 20 mutations, and on top of that, there are at least four different subtypes circulating in the world.
“The vaccine strategy is less complicated when it comes to getting the immune system to recognise a single virus than thousands of variants and at least four subtypes.”
The state of HIV research has benefitted coronavirus research, she added. “Vaccine strategies that were tested for HIV and did not work are being used for Covid-19 vaccines, including the adenovirus vaccine (used by AstraZeneca and Johnson & Johnson).
“There are interactions and lessons to be learned on both sides.” ‘
What are emergency use authorizations, and do they guarantee that a vaccine or drug is safe?- Dec 3, 2020
'The first time the FDA issued an EUA was in 2005 for an anthrax vaccine, but just for military personnel. In 2009, the FDA issued the first EUA for civilians, so that Tamiflu could be given to infants during the H1N1 pandemic.
The basic principle behind the EUA, however, originates from an earlier pandemic: HIV/AIDS, which first became visible in North America in 1981.
Emergency use authorizations can be seen as a form of scaling up these earlier pathways to accelerate approval. Since 2009, the FDA has since issued dozens of EUAs for drugs, devices and diagnostics based on the best available evidence for prevailing public health crises.
Different standards for different times
Public perceptions matter
A trade-off between continued testing and access
A trade-off between continued testing and access
EUAs present another problem if they short-circuit the clinical trial process. Why sign up for a 50% chance of receiving a placebo if you can have a 100% chance of receiving the same product through an EUA? Thus, an overly broad EUA can stymie ongoing participation in vaccine trials such that we may never really learn whether the product is safe and effective.
These fears are not new, and can be seen in the earliest debates around parallel-track designations for AIDS drugs. But they weigh more heavily in the scalar logic of pandemic-issued EUAs. Pandemics drive massive shifts in consumer demand that cause enormous supply and logistic problems (remember back when you had a hard time getting toilet paper?). In the short run, we will not have sufficient amounts of vaccine manufactured to support broad access to meet the full demand for new vaccines.'
What's the Difference Between Emergency Use Authorization and Approval?https://www.verywellhealth.com/emergency-use-authorization-vs-approval-5092864 - Dec 18, 2020
'According to the guidance, the FDA can grant an EUA for a vaccine if:
- The product may reasonably prevent, diagnose, or treat such serious or life-threatening disease or condition that can be caused by SARS-CoV-2.
- The known and potential benefits outweigh the known and potential risks.
- There is no adequate, approved, and available alternative to the product for diagnosing, preventing, or treating the disease or condition.'
Phantom Virus: In search of Sars-CoV-2
HIV VIRUS Controversy
About HIV- CDC
https://www.cdc.gov/hiv/basics/whatishiv.html. Page last reviewed: March 22, 2021
'HIV (human immunodeficiency virus) is a virus that attacks the body’s immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome).
Where did HIV come from?
- HIV infection in humans came from a type of chimpanzee in Central Africa.
-The chimpanzee version of the virus (called simian immunodeficiency virus, or SIV) was probably passed to humans when humans hunted these chimpanzees for meat and came in contact with their infected blood.
-Studies show that HIV may have jumped from chimpanzees to humans as far back as the late 1800s.a
-Over decades, HIV slowly spread across Africa and later into other parts of the world. We know that the virus has existed in the United States since at least the mid to late 1970s.'
( CDC- no references given)
Professor Peter Duesberg on HIV
'On the basis of his experience with retroviruses, Duesberg has challenged the virus-AIDS hypothesis in the pages of such journals as Cancer Research, Lancet, Proceedings of the National Academy of Sciences, Science, Nature, Journal of AIDS, AIDS Forschung, Biomedicine and Pharmacotherapeutics, New England Journal of Medicine and Research in Immunology. He has instead proposed the hypothesis that the various American/European AIDS diseases are brought on by the long-term consumption of recreational drugs and/or AZT itself, which is prescribed to prevent or treat AIDS. See The AIDS Dilemma: Drug diseases blamed on a passenger virus.
Prof. Duesberg's findings have been a thorn in the side of the medical establishment and drug companies since 1987. Instead of engaging in scientific debate, however, the only response has been to cut-off funding to further test Professor's Duesberg's hypothesis.'
Kary Mullis, Nobel Prize winner in Chemistry
'The following was written by Kary Mullis for the introduction to the book "Inventing the AIDS Virus" by Peter H. Duesberg (Regnery Publishing, INC; Washington DC, 1996):
We have not been able to discover any good reasons why most of the people on earth believe that AIDS is a disease caused by a virus called HIV. There is simply no scientific evidence demonstrating that this is true.
We have also not been able to discover why doctors prescribe a toxic drug called AZT (Zidovudine) to people who have no other complaint other than the fact that they have the presence of antibodies to HIV in their blood. In fact, we cannot understand why humans would take this drug for any reason.'
The Perth Group - The HIV- AIDS Debate
The Perth Group - Why HIV has never been discovered
(1 hour video)
'No evidence for the existence of HIV
Such evidence has up till now never been produced for HIV. No photograph of an isolated HIV particle has ever been published nor of any of its proteins or nucleic acids. No control experiments as mentioned above have been published to date. What has been shown are photographs of virus-like particles in cell cultures, but none of isolated viruses, let alone of a structure within the human body having the shape ascribed to HIV. What the whole world has seen are models representing HIV with dish aerials, said to be receptors with which the virus attaches itself to cells.
The existence of HIV is inferred from an antibody test, but how this is supposed to work, when the virus has never been shown to exist and obtained free of contaminants, remains a mystery.'
NO PARTICLE OF HIV HAS EVER BEEN OBTAINED PURE, FREE OF CONTAMINANTS; NOR HAS A COMPLETE PIECE OF HIV RNA (OR THE TRANSCRIBED DNA) EVER BEEN PROVED TO EXIST. *
15 YEARS OF AIDS -The continuous failure in the prevention and treatment of AIDS is rooted in the misinterpretation of an inflammatory auto immune process as a lethal, viral venereal disease
By A. Hässig, H. Kremer, S. LANKA, W-X Liang, K. Stampfli. -May 1998
'Summary - The question of the specificity of the anti-HIV antibody test has to be re-evaluated as it was shown that the viral enrichment obtained from co-cultivations of patients lymphocytes with fetal cord blood by BARRÉ-SINOUSSI et al. and leukaemia cells by GALLO et al., exclusively consisted of proteins of the cell types used in the cell culture. This precludes a clear separation of presumed retroviral and cellular proteins or extracellular matrix proteins. In this context it was shown that the anti-HIV antibody test detects autoimmune antibodies directed against cyto-skeletal proteins e.g. the liver cells. Strongly augmented anti-actin autoantibodies is considered close to pathognomonic for chronically active hepatitis. The original assumption that "reverse transcription" from RNA to DNA is evidence for the existence of retroviruses, was wrong. In fact, "reverse transcription" is a vital mechanism for the maintenance the genome. The decrease in numbers of circulating CD4 lymphocytes can be explained by a stress-induced hyper-cortisolism. Up to date, direct HIV-mediated destruction of CD4 lymphocytes could not be proved. The same is true for measuring of the "viral load". Shortcomings of the applied method to quantify the "viral load" do not permit definitive conclusions. Possibly, it may be taken as an expression of a stress-induced weakening of the cellular immune reactions, in the course of which the nucleoside fragments resulting from the current cell turnover are inadequately eliminated. Furthermore, the treatment of patients with nucleoside analogues has a toxic effect on both the genome of the cell-nucleus and the mitochondria. The latter, therefore, may produce insufficient amounts of ATP, causing organ failure and, eventually, death. The synthetic protease inhibitors used these days are associated with serious side-effects. Therefore, it seems worthwhile, in these patients, to bring back the catabolic situation due to whole body inflammation to homeostasis by administering anabolic phyto-polyphenolic compounds.'
'With this, you are not maintaining that the dangerous AIDS virus too is only a virtual one, are you?'
'Not only I am maintaining that the so-called AIDS virus "HIV" has never been scientifically demonstrated to exist, but only is being maintained to exist because of a purported consensus.'
'once more some deadly viruses are being maintained to exist, it should be obvious who in reality are the terrorists and who in reality are the suicide bombers: All who are participating in the virus panic and are contributing to it!’
Controversy over the existence and isolation of the viruses
-Dr Stefan Lanka- 'Not only I am maintaining that the so-called AIDS virus "HIV" has never been scientifically demonstrated to exist, but only is being maintained to exist because of a purported consensus.'
-Phantom Virus: In search of Sars-CoV-2'- has not been scientifically proven to exist .
The hunt for a vaccine
'How the hunt for an HIV vaccine is helping research into Covid-19 – and vice-versa.'
'The two viruses are nonetheless very different, she said, noting that vaccine strategies tested for HIV have not been successful, whereas several Covid-19 vaccines have been found in record time. '
Emergency Use Authorization - 'The basic principle behind the EUA, however, originates from an earlier pandemic: HIV/AIDS, which first became visible in North America in 1981.'
Covid-19 vaccine have been produced in record time and were given Emergency authorization without the trials being completed and alternatives, , like , Vit D., Zinc, hydroxycloroquine and ivermenctin ( https://pubmed.ncbi.nlm.nih.gov/33065103/) considered.
( 'According to the guidance, the FDA can grant an EUA for a vaccine if:
There is no adequate, approved, and available alternative to the product for diagnosing, preventing, or treating the disease or condition.)
'In the pandemic plans a possible breakdown of the provisioning and of public order, in connection with the declaring of a bird flu pandemic, has been envisaged by the WHO. '
'As being under threat I see all inhabitants of homes for the aged, who in a breaking-out of chaos and a breakdown of the provisioning systems, and with those the public order, will be the first, and besides small children the most protectionless and defenceless, victims. Hardly possble to depict would it be, if the contagious-disease makers would declare the emergency already during the winter.'
'Anyone who waits for "the others" to do something should not wonder if those others do nothing and the situation does not remain what it is but even gets much worse. In the final instance we, the citizens, stand behind this, in that we for years without doing anything about it have seen the whole madness around us and have tolerated it. Here we must begin to take social responsibility, if we do not want to surrender and sacrifice ourselves to the total domination and chaos of an uncontrolled pseudoscience.'