Phosphate Toxicity

Phosphate toxicity and tumorigenesis

2018 Apr;1869(2):303-309.
doi: 10.1016/j.bbcan.2018.04.007. Epub 2018 Apr 21.

High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling

2009 Jan 1;179(1):59-68.
 doi: 10.1164/rccm.200802-306OC.Epub 2008 Oct 10.

Dietary phosphate: what do we know about its toxicity

Sep-Oct 2013;26(5):856-64.
 doi: 10.5301/jn.5000242. Epub 2013 Jan 9.


Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be decreased with plant-based diets, phosphate binders, niacin, and avoidance of phosphate additives

Jul-Aug 2014;30(7-8):739-47.
 doi: 10.1016/j.nut.2013.12.010.Epub 2013 Dec 15.

'Dietary phosphate absorption can be moderated by emphasizing plant-based dietary choices (which provide phosphate in less bioavailable forms); avoidance of processed foods containing inorganic phosphate food additives; and by ingestion of phosphate-binder drugs, magnesium supplements, or niacin, which precipitate phosphate or suppress its gastrointestinal absorption. The propensity of dietary phosphate to promote vascular calcification may be opposed by optimal intakes of magnesium, vitamin K, and vitamin D; the latter should also counter the tendency of phosphate to elevate parathyroid hormone.'



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