Phosphate toxicity and tumorigenesis
High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling
Hua Jin, Cheng-Xiong Xu, Hwang-Tae Lim, Sung-Jin Park, Ji-Young Shin, Youn-Sun Chung, Se-Chang Park, Seung-Hee Chang, Hee-Jeong Youn, Kee-Ho Lee, Yeon-Sook Lee, Yoon-Cheol Ha, Chan-Hee Chae, George R Beck Jr, Myung-Haing Cho
2009 Jan 1;179(1):59-68.doi: 10.1164/rccm.200802-306OC.Epub 2008 Oct 10.
Dietary phosphate: what do we know about its toxicity
Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be decreased with plant-based diets, phosphate binders, niacin, and avoidance of phosphate additives
'Dietary phosphate absorption can be moderated by emphasizing plant-based dietary choices (which provide phosphate in less bioavailable forms); avoidance of processed foods containing inorganic phosphate food additives; and by ingestion of phosphate-binder drugs, magnesium supplements, or niacin, which precipitate phosphate or suppress its gastrointestinal absorption. The propensity of dietary phosphate to promote vascular calcification may be opposed by optimal intakes of magnesium, vitamin K, and vitamin D; the latter should also counter the tendency of phosphate to elevate parathyroid hormone.'
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